Anti-ELK4 Antibody (CAB18360)
- SKU:
- CAB18360
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-ELK4 Antibody |
Antibody SKU: | CAB18360 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human ELK4. |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: |
Immunogen: | Recombinant protein of human ELK4. |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 2005 |
Uniprot: | P28324 |
Cellular Location: | |
Calculated MW: | |
Observed MW: | Refer to figures |
Synonyms: | SAP1, ELK4 |
Background: |
UniProt Protein Function: | Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. |
NCBI Summary: | This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P28324 |
NCBI GenInfo Identifier: | 11496882 |
NCBI Gene ID: | 2005 |
NCBI Accession: | NP_068567 |
UniProt Related Accession: | P28324 |
Molecular Weight: | 45kDa |
NCBI Full Name: | ETS domain-containing protein Elk-4 isoform b |
NCBI Synonym Full Names: | ETS transcription factor ELK4 |
NCBI Official Symbol: | ELK4Â Â |
NCBI Official Synonym Symbols: | SAP1Â Â |
NCBI Protein Information: | ETS domain-containing protein Elk-4 |
UniProt Protein Name: | ETS domain-containing protein Elk-4 |
UniProt Synonym Protein Names: | Serum response factor accessory protein 1; SAP-1; SRF accessory protein 1 |
Protein Family: | ETS domain-containing protein |
UniProt Gene Name: | ELK4Â Â |