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Elk1 Transcription Factor Activity Assay

SKU:
TFAB00096
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Elk1
Reactivity:
Human
Mouse
€599
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Elk1 Transcription Factor Activity Assay
Product Code:TFAB00096
Target:Elk1
Reactivity:Human, Mouse
Sample Types:Nuclear or cell lysates

The Assay Genie Elk1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus

Molecular Function:chromatin binding; protein binding; transcription factor activity

Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter

NCBI Summary:This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
UniProt Code:P19419
NCBI GenInfo Identifier:12643407
NCBI Gene ID:2002
NCBI Accession:P19419.2
UniProt Secondary Accession:P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4,
UniProt Related Accession:P19419
Molecular Weight:
NCBI Full Name:ETS domain-containing protein Elk-1
NCBI Synonym Full Names:ELK1, ETS transcription factor
NCBI Official Symbol:ELK1  
NCBI Protein Information:ETS domain-containing protein Elk-1
UniProt Protein Name:ETS domain-containing protein Elk-1
Protein Family:ETS domain-containing protein
UniProt Gene Name:ELK1  
UniProt Entry Name:ELK1_HUMAN
AntibodiesELISA Kits
Anti-ELK1 Antibody (CAB0789)Elk1 (Phospho-Ser383) Colorimetric Cell-Based ELISA Kit
Anti-ELK1 Antibody (CAB19046)Elk1 (Phospho-Ser383) Transcription Factor Activity Assay
Anti-Phospho-ELK1-S383 Antibody (CABP0033)Elk1 (Phospho-Ser389) Transcription Factor Activity Assay
Anti-Phospho-ELK1-S383 Antibody (CABP0345)Elk1 (Phospho-Thr417) Transcription Factor Activity Assay
ELK1 Antibody (PACO00753)

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