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Elk1 (Phospho-Thr417) Transcription Factor Activity Assay

SKU:
TFAB00023
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
Elk1 (Phospho-Thr417)
Reactivity:
Human
Mouse
€599
Frequently bought together:

Description

system_update_altDatasheet

Elk1 (Phospho-Thr417)Transcription Factor Activity Assay

The Elk1 Phospho-Thr417 Transcription Factor Activity Assay is a powerful tool for studying the activity of Elk1, a transcription factor involved in regulating gene expression. This assay allows for the specific detection of Elk1 phosphorylation at threonine 417, providing valuable insights into intracellular signaling pathways and cellular responses to stimuli.With a high level of sensitivity and accuracy, this assay offers researchers reliable and reproducible results for a variety of experimental settings.

By measuring Elk1 activity, scientists can gain a better understanding of how this transcription factor controls gene expression and its role in various biological processes.Whether investigating signaling pathways, studying gene regulation, or developing potential therapies for diseases influenced by Elk1 activity, the Elk1 Phospho-Thr417 Transcription Factor Activity Assay is an essential tool for advancing research in molecular biology and cell signaling.

Product Name:Elk1 (Phospho-Thr417) Transcription Factor Activity Assay
Product Code:TFAB00023
Target:Elk1 (Phospho-Thr417)
Reactivity:Human, Mouse
Sample Types:Nuclear or cell lysates

The Assay Genie Elk1 (Phospho-Thr417) transcription factor activity assay allows for the detection and qualitative analysis of Elk1 (Phospho-Thr417) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:ELK1: a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: cell soma; dendrite; mitochondrion; nerve terminal; nucleoplasm; nucleus

Molecular Function:chromatin binding; protein binding; transcription factor activity

Biological Process: cell differentiation; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to light stimulus; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription from RNA polymerase II promoter

NCBI Summary:This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]
UniProt Code:P19419
NCBI GenInfo Identifier:12643407
NCBI Gene ID:2002
NCBI Accession:P19419.2
UniProt Secondary Accession:P19419,O75606, O95058, Q969X8, Q9UJM4, B2R7H4,
UniProt Related Accession:P19419
Molecular Weight:
NCBI Full Name:ETS domain-containing protein Elk-1
NCBI Synonym Full Names:ELK1, ETS transcription factor
NCBI Official Symbol:ELK1  
NCBI Protein Information:ETS domain-containing protein Elk-1
UniProt Protein Name:ETS domain-containing protein Elk-1
Protein Family:ETS domain-containing protein
UniProt Gene Name:ELK1  
UniProt Entry Name:ELK1_HUMAN
AntibodiesELISA Kits
Anti-ELK1 Antibody (CAB0789)Elk1 (Phospho-Ser383) Colorimetric Cell-Based ELISA Kit
Anti-ELK1 Antibody (CAB19046)Elk1 (Phospho-Ser383) Transcription Factor Activity Assay
Anti-Phospho-ELK1-S383 Antibody (CABP0033)Elk1 (Phospho-Ser389) Transcription Factor Activity Assay
Anti-Phospho-ELK1-S383 Antibody (CABP0345)Elk1 Transcription Factor Activity Assay
ELK1 Antibody (PACO00753)

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