null

ELAVL2/ELAVL4 Antibody (PACO02632)

SKU:
PACO02632
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

ELAVL2/ELAVL4 Antibody (PACO02632)

The ELAVL2/ELAVL4 Antibody (PACO02632) is a valuable tool for researchers studying RNA-binding proteins that play crucial roles in gene expression and post-transcriptional regulation. This polyclonal antibody, raised in rabbits, is highly specific for detecting ELAVL2 and ELAVL4 proteins in human samples, making it ideal for use in Western blot applications.ELAVL2 and ELAVL4 are members of the ELAVL family of RNA-binding proteins, known for their ability to regulate mRNA stability and translation. These proteins have been implicated in various cellular processes, including cell proliferation, differentiation, and apoptosis.

The ELAVL2/ELAVL4 Antibody allows for the detection and analysis of these important proteins in different cell types, providing valuable insights into their functions and potential roles in diseases such as cancer and neurodegenerative disorders.By understanding the expression and localization of ELAVL2 and ELAVL4, researchers can gain a better understanding of the molecular mechanisms underlying gene expression regulation and potentially identify novel therapeutic targets for the treatment of diseases associated with dysregulated RNA metabolism.

Antibody Name:ELAVL2/ELAVL4 Antibody
Antibody SKU:PACO02632
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human HuB/D.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ELAVL2; HUB; ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1; ELAVL4; HUD; PNEM; ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD
UniProt Protein Function:ELAVL2: Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR. Belongs to the RRM elav family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding

Chromosomal Location of Human Ortholog: 9p21.3

Cellular Component: nucleoplasm

Molecular Function:mRNA 3'-UTR binding; protein binding; RNA binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent

NCBI Summary:The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
UniProt Code:Q12926
NCBI GenInfo Identifier:93141258
NCBI Gene ID:1993
NCBI Accession:Q12926.2
UniProt Secondary Accession:Q12926,Q13235, Q59G15, Q8NEM4, Q9H1Q8, D3DRK3,
UniProt Related Accession:Q12926
Molecular Weight:40kDa
NCBI Full Name:ELAV-like protein 2
NCBI Synonym Full Names:ELAV like RNA binding protein 2
NCBI Official Symbol:ELAVL2  
NCBI Official Synonym Symbols:HUB; HELN1; HEL-N1  
NCBI Protein Information:ELAV-like protein 2
UniProt Protein Name:ELAV-like protein 2
UniProt Synonym Protein Names:ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1
Protein Family:ELAV-like protein
UniProt Gene Name:ELAVL2  

Related Products