The ELAVL1 Polyclonal Antibody (CAB6089) is a valuable tool for researchers studying ELAVL1, a protein involved in RNA metabolism and regulation of gene expression. This antibody, generated in rabbits, is highly specific to ELAVL1 and is validated for use in various applications, including Western blot and immunofluorescence.ELAVL1, also known as Hu antigen R (HuR), plays a crucial role in post-transcriptional regulation of gene expression by binding to target mRNAs and stabilizing them. Dysregulation of ELAVL1 has been linked to numerous diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
Studying ELAVL1 expression and function is essential for understanding its role in disease development and progression.The ELAVL1 Polyclonal Antibody (CAB6089) offers researchers a reliable tool for detecting and analyzing ELAVL1 protein levels in various cell types and tissues. By using this antibody, scientists can gain insights into the mechanisms by which ELAVL1 contributes to disease pathogenesis, potentially leading to the development of novel therapeutic strategies targeting ELAVL1-dependent pathways.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
Purification Method:
Affinity purification
Gene ID:
1994
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] HuR/ELAVL1 Rabbit pAb (CAB6089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
