The Elav-like Protein 2 Polyclonal Antibody (CAB5918) is a valuable tool for researchers studying Elav-like protein 2 (ELAVL2), a RNA-binding protein involved in RNA metabolism and gene expression regulation. This high-quality antibody, generated in rabbits, has been validated for specificity and sensitivity in Western blot applications, allowing for reliable detection and analysis of ELAVL2 in various cell types.ELAVL2 plays a key role in post-transcriptional regulation of gene expression, particularly in neuronal cells where it influences mRNA stability and translation.
Dysregulation of ELAVL2 has been linked to neurodegenerative disorders, such as Alzheimer's disease, making it a promising target for therapeutic interventions. By studying the function and expression of ELAVL2 using this antibody, researchers can gain insights into its involvement in neurobiology and potentially identify novel treatment strategies for neurological conditions.
Product Name:
ELAVL2 Rabbit Polyclonal Antibody
SKU:
CAB5918
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ELAVL2 (NP_004423.2).
In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms.
Purification Method:
Affinity purification
Gene ID:
1993
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ELAVL2 Rabbit pAb (CAB5918) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
