The Elav-like Protein 1 Polyclonal Antibody (CAB1608) is a valuable tool for researchers studying Elav-like Protein 1 (ELAVL1), a RNA-binding protein involved in post-transcriptional regulation of gene expression. This antibody, raised in rabbits, is highly specific for human ELAVL1 and has been validated for use in Western blot applications.ELAVL1, also known as Hu antigen R (HuR), plays a crucial role in controlling the stability and translation of mRNA molecules, impacting various cellular processes such as cell proliferation, apoptosis, and stress response.
Dysregulation of ELAVL1 has been implicated in several diseases including cancer, neurodegenerative disorders, and inflammatory conditions.By targeting ELAVL1, researchers can investigate its role in disease development and progression, as well as explore its potential as a therapeutic target. The Elav-like Protein 1 Polyclonal Antibody (CAB1608) provides a reliable tool for detecting and analyzing ELAVL1 in a variety of cell types, offering valuable insights into its function and potential implications for human health.
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
Purification Method:
Affinity purification
Gene ID:
1994
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] HuR/ELAVL1 Rabbit pAb (CAB1608) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
