The Elastin Polyclonal Antibody (CAB2723) is a valuable tool for research involving elastin, a key component of the extracellular matrix in various tissues, including skin, blood vessels, and lungs. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunohistochemistry.Elastin is essential for tissue elasticity and maintaining structural integrity, making it crucial for normal physiological functions. Dysregulation of elastin has been implicated in various diseases, including cardiovascular disorders, pulmonary diseases, and skin aging.
The Elastin Polyclonal Antibody enables the detection and analysis of elastin levels in different cell types and tissues, making it an invaluable tool for studies in regenerative medicine, tissue engineering, and age-related diseases. Understanding the regulation and function of elastin is essential for developing targeted therapies to restore tissue elasticity and function in pathological conditions. The Elastin Polyclonal Antibody provides researchers with a reliable tool to investigate the role of elastin in health and disease, paving the way for new treatment strategies and therapeutic interventions.
Product Name:
ELN Rabbit Polyclonal Antibody
SKU:
CAB2723
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ELN (NP_001265868.1).
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.
Purification Method:
Affinity purification
Gene ID:
2006
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ELN Rabbit pAb (CAB2723) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
