ELN Rabbit Polyclonal Antibody (CAB2723)
- SKU:
- CAB2723
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ELN Rabbit Polyclonal Antibody |
SKU: | CAB2723 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-200 of human ELN (NP_001265868.1). |
Sequence: | GGVP GAIP GGVP GGVF YPGA GLGA LGGG ALGP GGKP LKPV PGGL AGAG LGAG LGAF PAVT FPGA LVPG GVAD AAAA YKAA KAGA GLGG VPGV GGLG VSAG AVVP QPGA GVKP GKVP GVGL PGVY PGGV LPGA RFPG VGVL PGVP TGAG VKPK APGV GGAF AGIP GVGP FGGP QP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | WS; WBS; SVAS; ADCL1; ELN |
Positive Sample: | A-549,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 68kDa |
Observed MW: | 70kDa |
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa.
Purification Method: | Affinity purification |
Gene ID: | 2006 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |