ELANE Rabbit Polyclonal Antibody (CAB13015)
- SKU:
- CAB13015
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | ELANE Rabbit Polyclonal Antibody |
SKU: | CAB13015 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 30-267 of human Neutrophil Elastase (ELANE) (NP_001963.1). |
Sequence: | IVGG RRAR PHAW PFMV SLQL RGGH FCGA TLIA PNFV MSAA HCVA NVNV RAVR VVLG AHNL SRRE PTRQ VFAV QRIF ENGY DPVN LLND IVIL QLNG SATI NANV QVAQ LPAQ GRRL GNGV QCLA MGWG LLGR NRGI ASVL QELN VTVV TSLC RRSN VCTL VRGR QAGV CFGD SGSP LVCN GLIH GIAS FVRG GCAS GLYP DAFA PVAQ FVNW IDSI IQRS EDNP CPHP RDPD PASR TH |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; Neutrophil Elastase (ELANE) |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | cell surface, cytoplasm, cytosol, extracellular exosome, extracellular region, extracellular space, phagocytic vesicle |
Calculated MW: | 29kDa |
Observed MW: | 36kDa |
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19.
Purification Method: | Affinity purification |
Gene ID: | 1991 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |