ELAC2 Rabbit Polyclonal Antibody (CAB7128)
- SKU:
- CAB7128
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | ELAC2 Rabbit Polyclonal Antibody |
SKU: | CAB7128 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1). |
Sequence: | MWAL CSLL RSAA GRTM SQGR TISQ APAR RERP RKDP LRHL RTRE KRGP SGCS GGPN TVYL QVVA AGSR DSGA ALYV FSEF NRYL FNCG EGVQ RLMQ EHKL KVAR LDNI FLTR MHWS NVGG LSGM ILTL KETG LPKC VLSG PPQL EKYL EAIK IFSG PLKG IELA VRPH SAPE YEDE TMTV YQIP IHSE QRRG KHQP WQSP ERPL SRLS PERS SDSE SNEN EPHL PHGV SQRR GVRD SSLV VAFI CKLH LKRG NFLV LKAK EMGL PVGT AA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | ELC2; HPC2; COXPD17; ELAC2 |
Positive Sample: | MCF7,NCI-H460 |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion, Nucleus. |
Calculated MW: | 92kDa |
Observed MW: | 105kDa |
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 60528 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |