The ELAC1 Polyclonal Antibody (PAC041646) is a valuable tool for researchers studying ELAC1, a protein involved in RNA processing and mitochondrial function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It detects the ELAC1 protein, allowing for analysis in various cell types and tissues, making it ideal for studies in molecular biology and mitochondrial research.ELAC1 is a key player in RNA metabolism, specifically in the processing of tRNA molecules within the mitochondria. Dysregulation of ELAC1 has been linked to various diseases, including mitochondrial disorders and neurodegenerative conditions.
Investigating the function and expression of ELAC1 is crucial for understanding its role in disease pathology and developing targeted therapies. Overall, the ELAC1 Polyclonal Antibody is a reliable tool for researchers exploring the functions and mechanisms of ELAC1 in RNA processing and mitochondrial biology. Its specificity and sensitivity make it a valuable asset for studies aiming to unravel the role of ELAC1 in health and disease.
Antibody Name:
ELAC1 Antibody (PACO41646)
Antibody SKU:
PACO41646
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc phosphodiesterase ELAC protein 1 protein (1-363AA)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO41646 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41646 at dilution of 1:100.
Background:
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Synonyms:
Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1), ELAC1, D29
UniProt Protein Function:
ELAC1: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Belongs to the RNase Z family.Protein type: EC 3.1.26.11; RibonucleaseChromosomal Location of Human Ortholog: 18q21Cellular Component: cytosol; nucleusMolecular Function: 3'-tRNA processing endoribonuclease activity
