The EIPR1 Polyclonal Antibody (PAC036094) is a valuable tool for researchers studying EIPR1, a protein involved in endocytosis and intracellular trafficking. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the EIPR1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and neuroscience.EIPR1 plays a crucial role in the regulation of protein trafficking within cells, impacting processes such as receptor recycling and lysosomal degradation.
Dysfunction of EIPR1 has been linked to various neurodegenerative disorders and developmental abnormalities, making it a promising target for therapeutic interventions. By studying the function and regulation of EIPR1, researchers can gain insights into disease mechanisms and potential treatment strategies in the field of neuroscience.
Antibody Name:
EIPR1 Antibody (PACO36094)
Antibody SKU:
PACO36094
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human EARP and GARP complex-interacting protein 1 protein (201-387AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO36094 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO36094 at dilution of 1:100.
Background:
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.
Synonyms:
EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein), EIPR1, TSSC1
UniProt Protein Function:
TSSC1: Chromosomal Location of Human Ortholog: 2p25.3
UniProt Protein Details:
NCBI Summary:
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
