The EIF6 Polyclonal Antibody (CAB1818) is a valuable tool for researchers studying EIF6, a protein involved in ribosome biogenesis and translation initiation. This antibody, generated in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. It specifically binds to EIF6 protein, allowing for its detection and analysis in various cellular contexts.EIF6 is known to play a crucial role in protein synthesis, making it a key player in cellular growth and proliferation. Dysregulation of EIF6 has been implicated in various diseases, including cancer, where aberrant protein translation can promote tumor development.
By understanding the function of EIF6, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic targets.Overall, the EIF6 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of EIF6 in cellular processes and its potential implications in disease. Its high specificity and reactivity make it an essential component of studies in molecular biology, cancer research, and beyond.
Product Name:
EIF6 Rabbit Polyclonal Antibody
SKU:
CAB1818
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human EIF6 (NP_852133.1).
Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3692
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using EIF6 Rabbit pAb (CAB1818) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
