EIF4G1 Rabbit Polyclonal Antibody (CAB0881)
- SKU:
- CAB0881
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | EIF4G1 Rabbit Polyclonal Antibody |
SKU: | CAB0881 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human EIF4G1 (NP_886553.3). |
Sequence: | AGSN PGPE SEGS GVPP RPEE ADET WDSK EDKI HNAE NIQP GEQK YEYK SDQW KPLN LEEK KRYD REFL LGFQ FIFA SMQK PEGL PHIS DVVL DKAN KTPL R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1; EIF4G1 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, nucleus, postsynapse |
Calculated MW: | 175kDa |
Observed MW: | 250kDa |
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Purification Method: | Affinity purification |
Gene ID: | 1981 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |