eIF4EBP1 Polyclonal Antibody (CAB21386)
- SKU:
- CAB21386
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
Frequently bought together:
Description
Product Name: | eIF4EBP1 Polyclonal Antibody |
SKU: | CAB21386 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-118 of human eIF4EBP1. (NP_004086.1). |
Sequence: | TRII YDRK FLME CRNS PVTK TPPR DLPT IPGV TSPS SDEP PMEA SQSH LRNS PEDK RAGG EESQ FEMD I |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BP-1; 4EBP1; 4E-BP1; PHAS-I; P1 |
Positive Sample: | K-562,HCT 116,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol |
Calculated MW: | 13kDa |
Observed MW: | Refer to figures |
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Purification Method: | Affinity purification |
Gene ID: | 1978 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |