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Anti-EIF3L Antibody (CAB9972)

SKU:
CAB9972
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
  • Metabolism Antibodies 3 Anti-EIF3L Antibody CAB9972
  • Metabolism Antibodies 3 Anti-EIF3L Antibody CAB9972
  • Metabolism Antibodies 3 Anti-EIF3L Antibody CAB9972
€139 - €419
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Description

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Antibody Name:Anti-EIF3L Antibody
Antibody SKU:CAB9972
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:4000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, HT-1080, NIH/3T3, Mouse heart, Mouse pancreas, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human EIF3L (NP_057175.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSYP ADDY ESEA AYDP YAYP SDYD MHTG DPKQ DLAY ERQY EQQT YQVI PEVI KNFI QYFH KTVS DLID QKVY ELQA SRVS SDVI DQKV YEIQ DIYE NSWT KLTE RFFK NTPW PEAE AIAP QVGN DAVF LILY KELY YRHI YAKV SGGP SLEQ RFES YYNY CNLF NYIL NADG PAPL ELPN QWLW DIID EFIY QFQS FSQY RCKT AKKS EEEI DFLR SNPK IWNV HSVL NV
Gene ID:51386
Uniprot:Q9Y262
Cellular Location:Cytoplasm
Calculated MW:61kDa/66kDa
Observed MW:67kDa
Synonyms:EIF3L, EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005
Background:
UniProt Protein Function:eIF3S6IP: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Belongs to the eIF-3 subunit L family.
UniProt Protein Details:

Protein type:RNA-binding; Translation; Translation initiation

Chromosomal Location of Human Ortholog: 22q

Cellular Component: cytosol; eukaryotic translation initiation factor 3 complex; fibrillar center; membrane; nucleoplasm

Molecular Function:protein binding; translation initiation factor activity

Biological Process: cellular protein metabolic process; formation of translation preinitiation complex; gene expression; regulation of translational initiation; translation; translational initiation

UniProt Code:Q9Y262
NCBI GenInfo Identifier:339275831
NCBI Gene ID:51386
NCBI Accession:NP_001229852.1
UniProt Secondary Accession:Q9Y262,Q53HQ1, Q53HT4, Q5QTR1, Q5TI15, Q6ICD2, B2RDG6 B4DYB2, G8JLH4,
UniProt Related Accession:Q9Y262
Molecular Weight:Calculated MW: 61kDa/66kDaObserved MW: 67kDa
NCBI Full Name:eukaryotic translation initiation factor 3 subunit L isoform 2
NCBI Synonym Full Names:eukaryotic translation initiation factor 3 subunit L
NCBI Official Symbol:EIF3L  
NCBI Official Synonym Symbols:EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP  
NCBI Protein Information:eukaryotic translation initiation factor 3 subunit L
UniProt Protein Name:Eukaryotic translation initiation factor 3 subunit L
UniProt Synonym Protein Names:Eukaryotic translation initiation factor 3 subunit 6-interacting protein
UniProt Gene Name:EIF3L  
UniProt Entry Name:EIF3L_HUMAN
Anti-EIF3L Polyclonal Antibody (CAB9972)Western blot analysis of extracts of various cell lines, using EIF3L antibody (CAB9972) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-EIF3L Polyclonal Antibody (CAB9972)Immunohistochemistry of paraffin-embedded human liver cancer using EIF3L antibody (CAB9972) at dilution of 1:100 (40x lens).
Anti-EIF3L Polyclonal Antibody (CAB9972)Immunohistochemistry of paraffin-embedded human mammary cancer using EIF3L antibody (CAB9972) at dilution of 1:100 (40x lens).

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