The EIF2D Antibody (PAC010244) is a crucial tool for researchers investigating EIF2D, a protein involved in the regulation of translation initiation in eukaryotic cells. This polyclonal antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blot assays. By binding to the EIF2D protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and protein synthesis.EIF2D, also known as eukaryotic translation initiation factor 2D, plays a key role in the initiation of protein synthesis by facilitating the assembly of ribosomal pre-initiation complexes.
Its function in translation regulation makes it a target of interest for research into cellular processes, gene expression, and protein production. By studying EIF2D, researchers can gain valuable insights into mechanisms underlying various biological pathways and diseases.Investigating the function and regulation of EIF2D is essential for understanding fundamental cellular processes and developing therapeutics targeting protein synthesis. The EIF2D Antibody provides a powerful tool for researchers aiming to uncover the intricacies of translation initiation and its implications in health and disease.
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
UniProt Protein Details:
NCBI Summary:
This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
