The EIF2B5 Polyclonal Antibody (CAB10263) is specifically designed for research involving EIF2B5, a subunit of the eukaryotic translation initiation factor 2B complex. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the EIF2B5 protein, this antibody allows for the detection and analysis of EIF2B5 expression in a variety of cell types, making it ideal for studies in molecular biology and protein synthesis research.EIF2B5 is a critical component of the translation initiation machinery, playing a key role in protein synthesis regulation.
Dysregulation of EIF2B5 has been implicated in various diseases, including neurodegenerative disorders and cancers. Therefore, understanding the function and regulation of EIF2B5 is essential for unraveling the molecular mechanisms underlying these conditions and identifying potential therapeutic targets.By utilizing the EIF2B5 Polyclonal Antibody (CAB10263), researchers can gain valuable insights into the role of EIF2B5 in cellular processes and disease pathogenesis, ultimately advancing our understanding of gene expression control and paving the way for the development of novel therapeutic strategies.
Product Name:
eIF2B epsilon (EIF2B5) Rabbit Polyclonal Antibody
SKU:
CAB10263
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 442-721 of human eIF2B epsilon (eIF2B epsilon (EIF2B5)) (NP_003898.2).
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.
Purification Method:
Affinity purification
Gene ID:
8893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using eIF2B epsilon (EIF2B5) Rabbit pAb (CAB10263) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
