The EIF2B3 Polyclonal Antibody (CAB10262) is a valuable tool for researchers studying EIF2B3, a key regulatory protein involved in the initiation of protein synthesis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.EIF2B3 is a subunit of the eukaryotic translation initiation factor 2B (eIF2B) complex, which plays a critical role in the control of protein synthesis in response to cellular stress. Dysregulation of EIF2B3 has been implicated in a variety of diseases, including neurodegenerative disorders and cancer.
By detecting and analyzing EIF2B3 protein levels, researchers can gain insight into the mechanisms underlying these diseases and potentially identify new therapeutic targets. The EIF2B3 Polyclonal Antibody is a valuable tool for exploring the role of EIF2B3 in cellular pathways and disease progression, making it an essential component of any research involving protein synthesis and cellular stress response.
Product Name:
EIF2B3 Rabbit Polyclonal Antibody
SKU:
CAB10262
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EIF2B3 (NP_065098.1).
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EIF2B3 antibody (CAB10262) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
