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Anti-EIF2AK4 Antibody (CAB7155)

SKU:
CAB7155
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-EIF2AK4 Antibody CAB7155
  • Immunology Antibodies 2 Anti-EIF2AK4 Antibody CAB7155
  • Immunology Antibodies 2 Anti-EIF2AK4 Antibody CAB7155
€139 - €419

Description

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Anti-EIF2AK4 Antibody (CAB7155)

The EIF2AK4 Polyclonal Antibody (CAB7155) is a valuable tool for research into EIF2AK4, a key regulator of cellular response to stress and inflammation. The antibody, generated in rabbits, exhibits high specificity and sensitivity to human samples, making it ideal for use in Western blot applications. By binding to the EIF2AK4 protein, this antibody enables precise detection and analysis in various cell types, facilitating research in immunology, oncology, and inflammatory diseases.EIF2AK4, also known as GCN2, is a crucial player in the integrated stress response pathway, regulating protein synthesis in response to nutrient deprivation and cellular stress.

Dysregulation of EIF2AK4 function has been implicated in various diseases, including cancer, metabolic disorders, and neurodegenerative conditions. Targeting EIF2AK4 could hold therapeutic potential for treating these diseases by modulating cellular stress responses.In conclusion, the EIF2AK4 Polyclonal Antibody (CAB7155) is a valuable tool for researchers studying EIF2AK4 and its role in cellular stress responses and disease pathogenesis. Its high specificity and reactivity make it a reliable resource for advancing our understanding of EIF2AK4 biology and exploring potential therapeutic interventions.

Antibody Name:Anti-EIF2AK4 Antibody
Antibody SKU:CAB7155
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EIF2AK4 (NP_001013725.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EIF2AK4 (NP_001013725.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGG RGAP GRGR DEPP ESYP QRQD HELQ ALEA IYGA DFQD LRPD ACGP VKEP PEIN LVLY PQGL TGEE VYVK VDLR VKCP PTYP DVVP EIEL KNAK GLSN ESVN LLKS RLEE LAKK HCGE VMIF ELAY HVQS FLSE HNKP PPKS FHEE MLER RAQE EQQR LLEA KRKE EQEQ REIL HEIQ RRKE EIKE EKKR KEMA KQER LEIA SLSN QDHT SKKD PGGH RTAA ILHG GSPD FVGN GKHR ANSS GRSR RERQ YSVC NSED SPGS CEIL YFNM GSPD QLMV HKGK CIGS DEQL GKLV YNAL
Gene ID:440275
Uniprot:Q9P2K8
Cellular Location:
Calculated MW:69kDa/183kDa/186kDa
Observed MW:220kDa
Synonyms:EIF2AK4, GCN2, PVOD2
Background:This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
UniProt Protein Function:GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
UniProt Protein Details:

Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Translation; Other group; PEK family; GCN2 subfamily

Chromosomal Location of Human Ortholog: 15q15.1

Molecular Function:protein serine/threonine kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding

Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation

Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive

NCBI Summary:This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
UniProt Code:Q9P2K8
NCBI GenInfo Identifier:296439368
NCBI Gene ID:440275
NCBI Accession:Q9P2K8.3
UniProt Secondary Accession:Q9P2K8,Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5 Q9UJ56, C9JEC4,
UniProt Related Accession:Q9P2K8
Molecular Weight:
NCBI Full Name:Eukaryotic translation initiation factor 2-alpha kinase 4
NCBI Synonym Full Names:eukaryotic translation initiation factor 2 alpha kinase 4
NCBI Official Symbol:EIF2AK4  
NCBI Official Synonym Symbols:GCN2; PVOD2  
NCBI Protein Information:eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase; general control nonderepressible 2
UniProt Protein Name:Eukaryotic translation initiation factor 2-alpha kinase 4
UniProt Synonym Protein Names:GCN2-like protein
UniProt Gene Name:EIF2AK4  
UniProt Entry Name:E2AK4_HUMAN
Anti-EIF2AK4 Antibody (CAB7155)Western blot analysis of extracts of HepG2 cells, using EIF2AK4 antibody (CAB7155) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 30s.
Anti-EIF2AK4 Antibody (CAB7155)Immunohistochemistry of paraffin-embedded rat brain using EIF2AK4 antibody (CAB7155) at dilution of 1:100 (40x lens).
Anti-EIF2AK4 Antibody (CAB7155)Immunohistochemistry of paraffin-embedded human esophageal cancer using EIF2AK4 antibody (CAB7155) at dilution of 1:100 (40x lens).

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