EIF2AK3 Rabbit Polyclonal Antibody (CAB18196)
- SKU:
- CAB18196
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | EIF2AK3 Rabbit Polyclonal Antibody |
SKU: | CAB18196 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 867-1116 of human PERK (NP_004827.4). |
Sequence: | LTKN TTEK LQPS SPKV YLYI QMQL CRKE NLKD WMNG RCTI EERE RSVC LHIF LQIA EAVE FLHS KGLM HRDL KPSN IFFT MDDV VKVG DFGL VTAM DQDE EEQT VLTP MPAY ARHT GQVG TKLY MSPE QIHG NSYS HKVD IFSL GLIL FELL YPFS TQME RVRT LTDV RNLK FPPL FTQK YPCE YVMV QDML SPSP MERP EAIN IIEN AVFE DLDF PGKT VLRQ RSRS LSSS GTKH SRQS NNSH SPLP SN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IHC-P,1:100 - 1:500 |
Synonyms: | PEK; WRS; PERK |
Positive Sample: | Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Single-pass type I membrane protein. |
Calculated MW: | 125kDa |
Observed MW: | 140kDa |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Purification Method: | Affinity purification |
Gene ID: | 9451 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |