The EHMT1 Polyclonal Antibody (CAB8513) is a valuable tool for researchers studying the EHMT1 protein, which plays a key role in epigenetic regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the EHMT1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in epigenetics and gene regulation research.EHMT1, also known as euchromatic histone-lysine N-methyltransferase 1, is a histone methyltransferase enzyme that modifies chromatin structure to regulate gene expression.
Dysregulation of EHMT1 has been associated with various diseases, including neurodevelopmental disorders and cancer. Therefore, understanding the role of EHMT1 in epigenetic processes is crucial for developing targeted therapies and interventions in these disease contexts.Overall, the EHMT1 Polyclonal Antibody (CAB8513) offers researchers a reliable tool for investigating the function and regulation of EHMT1, ultimately contributing to advancements in the fields of epigenetics and gene expression studies.
Product Name:
EHMT1 Rabbit Polyclonal Antibody
SKU:
CAB8513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human EHMT1 (NP_079033.4).
The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
79813
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using EHMT1 Rabbit pAb (CAB8513) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 180s.
