EGR1/EGR2 Antibody (PACO00745)
- SKU:
- PACO00745
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
EGR1/EGR2 Antibody (PACO00745)
The EGR1/ EGR2 Antibody (PACO00745) is a valuable tool for researchers studying the Early Growth Response (EGR) family of transcription factors, which play key roles in cellular growth, differentiation, and response to various stimuli. This polyclonal antibody, produced in rabbits, boasts high reactivity with human samples and is validated for use in Western blot applications.By specifically targeting the EGR1 and EGR2 proteins, this antibody allows for the detection and analysis of these important transcription factors in a variety of cell types, making it an essential tool for studies in molecular biology, oncology, and developmental biology.
Understanding the regulation and activity of EGR1 and EGR2 is essential for unraveling their impact on gene expression and cellular processes, offering insights into diseases such as cancer, neurological disorders, and immune dysregulation.With its robust reactivity and specificity, the EGR1/ EGR2 Antibody (PACO00745) is a valuable asset for researchers seeking to delve deeper into the intricate mechanisms governed by the EGR transcription factors, paving the way for advancements in therapeutic interventions and disease management.
| Antibody Name: | EGR1/EGR2 Antibody |
| Antibody SKU: | PACO00745 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Egr-2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | EGR1; KROX24; ZNF225; Early growth response protein 1; EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24; EGR2; KROX20 |
| UniProt Protein Function: | EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor binding; transcription factor activity Biological Process: regulation of long-term neuronal synaptic plasticity; circadian rhythm; response to nutrient levels; transcription from RNA polymerase II promoter; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; response to ethanol; learning and/or memory; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; T cell differentiation; regulation of protein sumoylation; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P18146 |
| NCBI GenInfo Identifier: | 119242 |
| NCBI Gene ID: | 1958 |
| NCBI Accession: | P18146.1 |
| UniProt Related Accession: | P18146 |
| Molecular Weight: | 543 |
| NCBI Full Name: | Early growth response protein 1 |
| NCBI Synonym Full Names: | early growth response 1 |
| NCBI Official Symbol: | EGR1Â Â |
| NCBI Official Synonym Symbols: | TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268Â Â |
| NCBI Protein Information: | early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A |
| UniProt Protein Name: | Early growth response protein 1 |
| UniProt Synonym Protein Names: | AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24 |
| Protein Family: | Early growth response protein |
| UniProt Gene Name: | EGR1Â Â |
| UniProt Entry Name: | EGR1_HUMAN |
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