Prolyl hydroxylase PHD1 (EGLN2) Rabbit Polyclonal Antibody (CAB2252)
- SKU:
- CAB2252
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Prolyl hydroxylase PHD1 (EGLN2) Rabbit Polyclonal Antibody |
SKU: | CAB2252 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Prolyl hydroxylase PHD1 (EGLN2) (NP_444274.1). |
Sequence: | AALG GRVL AEVE ALKR GGRL RDGQ LVSQ RAIP PRSI RGDQ IAWV EGHE PGCR SIGA LMAH VDAV IRHC AGRL GSYV INGR TKAM VACY PGNG LGYV RHVD N |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | EIT6; PHD1; EIT-6; HPH-1; HPH-3; HIFPH1; HIF-PH1; Prolyl hydroxylase PHD1 (EGLN2) |
Positive Sample: | HeLa,A-549,HepG2,U-87MG,MCF-7,Mouse brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 44kDa |
Observed MW: | 43kDa |
The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene.
Purification Method: | Affinity purification |
Gene ID: | 112398 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |