EGFR (L858R) Rabbit Monoclonal Antibody (CAB5031)
- SKU:
- CAB5031
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERBB
- ERBB1
- HER1
- NISBD2
- PIG61
- mENA
Frequently bought together:
Description
Product Name: | EGFR (L858R) Rabbit Monoclonal Antibody |
SKU: | CAB5031 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human EGFR (L858R) (P00533). |
Sequence: | DYVR EHKD NIGS QYLL NWCV QIAK GMNY LEDR RLVH RDLA ARNV LVKT PQHV KITD FGLA KLLG AEEK EYHA EGGK VPIK WMAL ESIL HRIY THQS DVWS Y |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2; EGFR (L858R) |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 134kDa |
Observed MW: | 175kDa |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Purification Method: | Affinity purification |
Gene ID: | 1956 |
Clone Number: | ARC1139 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |