The EGFL6 Polyclonal Antibody (PAC037690) is a powerful tool for researchers studying EGFL6, a protein belonging to the epidermal growth factor (EGF) repeat superfamily. This antibody, developed in rabbits, exhibits high specificity for human samples and has been rigorously tested for Western blot applications. By binding to EGFL6, researchers can accurately detect and analyze this protein in various cell types, making it an excellent choice for studies in developmental biology and cancer research.EGFL6 is known for its involvement in processes such as cell growth, differentiation, and angiogenesis, making it a key player in development and disease.
The ability of EGFL6 to regulate cell behavior and promote tumor growth has led to increasing interest in its potential as a therapeutic target for cancer treatment. By exploring the functions and mechanisms of EGFL6, researchers can gain valuable insights into its role in cancer progression and potentially identify new strategies for intervention.
Western blot. All lanes: EGFL6 antibody at 6µg/ml. Lane 1: K562 whole cell lysate. Lane 2: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 62 kDa. Observed band size: 62 kDa.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO37690 at dilution of 1:100.
Background:
May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity).
Synonyms:
Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein), EGFL6, MAEG
UniProt Protein Function:
EGFL6: May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Belongs to the nephronectin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: Xp22Cellular Component: extracellular space; membrane; basement membraneMolecular Function: integrin binding; calcium ion bindingBiological Process: extracellular matrix organization and biogenesis; multicellular organismal development; cell cycle; cell adhesion; cell differentiation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]
