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EGF Receptor (E746-A750del Specific) Polyclonal Antibody

SKU:
CAB23256
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

EGF Receptor (E746-A750del Specific) Polyclonal Antibody (CAB23256)

The EGF Receptor E746-A750del Specific Polyclonal Antibody is a valuable tool for researchers studying a specific mutation in the EGF receptor that is commonly found in non-small cell lung cancers. This antibody, produced in rabbits, is highly specific and has been validated for use in various applications, including Western blotting and immunohistochemistry.The E746-A750del mutation in the EGF receptor results in the deletion of amino acids 746 to 750, leading to constitutive activation of the receptor and driving cancer cell growth and proliferation.

By using this antibody, researchers can accurately detect and analyze the presence of this mutation in cancer cell lines and patient samples, allowing for a better understanding of the role of this mutation in cancer development and progression.With its high specificity and reliability, the EGF Receptor E746-A750del Specific Polyclonal Antibody is a valuable tool for researchers interested in studying the molecular mechanisms underlying non-small cell lung cancer and exploring potential therapeutic strategies targeting the EGF receptor mutation.

Product Name:EGF Receptor (E746-A750del Specific) Polyclonal Antibody
Product Code:CAB23256
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:HCC827, NCI-H1975(Negative control)

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Immunogen:Recombinant protein of Human EGF Receptor (E746-A750del Specific).
Sequence:Email for sequence
Synonyms:ERBB, ERRP, HER1, mENA, ERBB1, PIG61, NISBD2
Calculated MW:134kDa
Observed MW:175kDa

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