EFS Rabbit Polyclonal Antibody (CAB16479)
- SKU:
- CAB16479
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | EFS Rabbit Polyclonal Antibody |
SKU: | CAB16479 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-190 of human EFS (NP_115835.1). |
Sequence: | TALR VPSS GPYD CPAS FSHP LTRV APQP PGED DAPY DVPL TPKP PAEL EPDL EWEG GREP GPPI YAAP SNLK RASA LLNL YEAP EELL ADGE GGGT DEGI YDVP LLGP EAPP SPEP PGAL ASHD QDTL AQL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SIN; CAS3; EFS1; EFS2; HEFS; CASS3; EFS |
Positive Sample: | Mouse thymus |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, focal adhesion |
Calculated MW: | 59kDa |
Observed MW: | 75kDa |
The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 10278 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |