EFEMP1 Antibody (PACO47378)
- SKU:
- PACO47378
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
EFEMP1 Antibody (PACO47378)
The EFEMP1 Polyclonal Antibody (PACO47378) is a valuable tool for research involving EFEMP1, a protein associated with extracellular matrix organization and cell adhesion. This antibody, generated in rabbits, exhibits high reactivity with human EFEMP1 samples and is validated for use in Western blot applications. By specifically binding to EFEMP1, researchers can detect and analyze this protein in a variety of cell types, making it well-suited for studies in molecular biology and tissue engineering.EFEMP1, also known as fibulin-3, plays a crucial role in maintaining the structural integrity of tissues and organs by supporting cell adhesion and migration. Dysregulation of EFEMP1 has been linked to various diseases, including cancer and age-related macular degeneration, highlighting its importance as a therapeutic target.
Investigating the function of EFEMP1 is essential for developing interventions that target its activity and restore tissue homeostasis in disease settings.In conclusion, the EFEMP1 Polyclonal Antibody (PACO47378) is a reliable tool for researchers studying EFEMP1's role in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it an excellent choice for investigations into the molecular mechanisms underlying tissue remodeling and pathology, paving the way for potential therapeutic advancements in the future.
| Antibody Name: | EFEMP1 Antibody (PACO47378) |
| Antibody SKU: | PACO47378 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human EGF-containing fibulin-like extracellular matrix protein 1 protein (27-184AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO47378 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO47378 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
| Synonyms: | EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3), EFEMP1, FBLN3 FBNL |
| UniProt Protein Function: | EFEMP1: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD); also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: extracellular matrix; extracellular region; extracellular space Molecular Function:epidermal growth factor receptor activity; epidermal growth factor receptor binding; protein binding Biological Process: camera-type eye development; embryonic eye morphogenesis; epidermal growth factor receptor signaling pathway; negative regulation of chondrocyte differentiation; peptidyl-tyrosine phosphorylation; post-embryonic eye morphogenesis; regulation of transcription, DNA-dependent; visual perception Disease: Doyne Honeycomb Retinal Dystrophy |
| NCBI Summary: | This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] |
| UniProt Code: | Q12805 |
| NCBI GenInfo Identifier: | 9973182 |
| NCBI Gene ID: | 2202 |
| NCBI Accession: | Q12805.2 |
| UniProt Secondary Accession: | Q12805,Q541U7, A8K3I4, B4DW75, D6W5D2, |
| UniProt Related Accession: | Q12805 |
| Molecular Weight: | 39,195 Da |
| NCBI Full Name: | EGF-containing fibulin-like extracellular matrix protein 1 |
| NCBI Synonym Full Names: | EGF containing fibulin like extracellular matrix protein 1 |
| NCBI Official Symbol: | EFEMP1Â Â |
| NCBI Official Synonym Symbols: | DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3Â Â |
| NCBI Protein Information: | EGF-containing fibulin-like extracellular matrix protein 1 |
| UniProt Protein Name: | EGF-containing fibulin-like extracellular matrix protein 1 |
| UniProt Synonym Protein Names: | Extracellular protein S1-5; Fibrillin-like protein; Fibulin-3; FIBL-3 |
| UniProt Gene Name: | EFEMP1Â Â |
| Antibodies | ELISA Kits |
| EFEMP1 Antibody (PACO02703) | Human FBLN3(Fibulin-3) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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EFEMP1 Antibody (PACO02703)
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