The EED Polyclonal Antibody (CAB12776) is a vital tool for researchers studying the EED protein, a key component of the Polycomb repressive complex 2 (PRC2) involved in epigenetic regulation. This antibody, produced in rabbits, is highly specific for detecting EED in human samples and is validated for use in Western blot applications. By binding to the EED protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studies in epigenetics, gene regulation, and developmental biology.EED is known for its role in gene silencing and chromatin compaction, making it a crucial player in the regulation of gene expression and cellular differentiation.
Dysregulation of EED has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions. Understanding the function of EED is essential for unraveling its contribution to these diseases and developing targeted therapies.Overall, the EED Polyclonal Antibody (CAB12776) is a valuable resource for researchers looking to delve into the intricacies of epigenetic regulation and gene expression, paving the way for new insights into disease mechanisms and potential therapeutic interventions.
Product Name:
EED Rabbit Polyclonal Antibody
SKU:
CAB12776
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EED (NP_003788.2).
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
8726
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EED Rabbit pAb (CAB12776) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
