The EDNRB Polyclonal Antibody (CAB2908) is a valuable tool for researchers studying the role of Endothelin Receptor Type B (EDNRB) in various biological processes. EDNRB is a G-protein coupled receptor involved in the regulation of blood pressure, cell proliferation, and migration.This polyclonal antibody, produced in rabbits, has high reactivity with human samples and is specifically validated for use in Western blot applications. It binds to the EDNRB protein, allowing for accurate detection and analysis in a variety of cell types. This makes it an ideal choice for studies in cardiovascular biology, cancer research, and developmental biology.
The EDNRB receptor is known to play a critical role in vascular development, melanocyte migration, and the progression of certain cancers. Understanding the mechanisms of EDNRB signaling is essential for developing targeted therapies for conditions such as pulmonary arterial hypertension, neuroblastoma, and melanoma.Overall, the EDNRB Polyclonal Antibody (CAB2908) is a reliable tool for researchers seeking to unravel the complexities of EDNRB function and its implications in human health and disease.
Product Name:
EDNRB Rabbit Polyclonal Antibody
SKU:
CAB2908
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human EDNRB (NP_001116131.1).
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1910
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EDNRB antibody (CAB2908) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
