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EDNRA Antibody (PACO00782)

SKU:
PACO00782
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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EDNRA Antibody (PACO00782)

Thank you for providing the product description template. Now, based on the information from the provided URL, here is a product description for the EDNRA Antibody (PACO00782):The EDNRA Antibody (PACO00782) is a high-quality antibody designed for research involving EDNRA, a cell surface receptor that plays a crucial role in regulating various physiological processes, particularly in the cardiovascular system. This antibody, produced and validated for use in Western blot applications, is raised in rabbits and exhibits high reactivity with human samples.EDNRA, also known as Endothelin A Receptor, is involved in mediating the effects of endothelin-1, a potent vasoconstrictor peptide implicated in cardiovascular diseases such as hypertension and heart failure.

By targeting the EDNRA protein, researchers can investigate its role in vascular function, smooth muscle contraction, and cellular signaling pathways, offering valuable insights into cardiovascular physiology and pathophysiology.Understanding the molecular mechanisms underlying EDNRA signaling is essential for developing targeted therapies for cardiovascular conditions and other diseases influenced by endothelin-1 activity. The EDNRA Antibody (PACO00782) provides a reliable tool for detecting and analyzing EDNRA expression in various experimental settings, facilitating research in cardiovascular biology, pharmacology, and drug discovery.

Antibody Name:EDNRA Antibody
Antibody SKU:PACO00782
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human ETAR.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EDNRA; ETA; ETRA; Endothelin-1 receptor; Endothelin A receptor; ET-A; ETA-R; hET-AR
UniProt Protein Function:EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.22

Cellular Component: nuclear membrane; integral to plasma membrane; T-tubule; plasma membrane; lipid raft

Molecular Function:endothelin receptor activity; protein binding; phosphoinositide phospholipase C activity

Biological Process: positive regulation of odontogenesis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); neural crest cell development; metabolic process; heart development; smooth muscle cell proliferation; response to morphine; response to lipopolysaccharide; glucose transport; sensory perception of pain; signal transduction; enteric nervous system development; Rho protein signal transduction; regulation of epithelial cell proliferation; histamine secretion; elevation of cytosolic calcium ion concentration; negative regulation of cAMP biosynthetic process; smooth muscle contraction; fibroblast proliferation; regulation of blood pressure; protein kinase C activation; positive regulation of cell proliferation; artery smooth muscle contraction; aging; penile erection; vasoconstriction; in utero embryonic development; glomerular filtration; adenylate cyclase activation; respiratory gaseous exchange; patterning of blood vessels; cell proliferation; G-protein coupled receptor protein signaling pathway; phospholipase C activation; maternal process involved in parturition; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of apoptosis; positive regulation of inflammatory response

Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1

NCBI Summary:This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Code:P25101
NCBI GenInfo Identifier:119606
NCBI Gene ID:1909
NCBI Accession:P25101.1
UniProt Secondary Accession:P25101,O43441, Q16432, Q16433, Q8TBH2, B2R723, B4E2V6 B7Z9G6, D3DP03, E7ER36,
UniProt Related Accession:P25101,AAB24923
Molecular Weight:23,803 Da
NCBI Full Name:Endothelin-1 receptor
NCBI Synonym Full Names:endothelin receptor type A
NCBI Official Symbol:EDNRA  
NCBI Official Synonym Symbols:ETA; ET-A; ETAR; ETRA; ETA-R; hET-AR  
NCBI Protein Information:endothelin-1 receptor; G protein-coupled receptor; endothelin receptor subtype A; endothelin-1-specific receptor
UniProt Protein Name:Endothelin-1 receptor
UniProt Synonym Protein Names:Endothelin A receptor; ET-A; ETA-R; hET-AR
Protein Family:Endothelin-1 receptor
UniProt Gene Name:EDNRA  
UniProt Entry Name:EDNRA_HUMAN

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