The EDARADD Polyclonal Antibody (CAB15951) is a valuable tool for researchers studying EDARADD, a protein involved in the NF-kappa-B signaling pathway. This antibody, generated in rabbits, is specifically reactive with human samples and is validated for use in Western blot applications. By binding to the EDARADD protein, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in inflammation, immune response, and cancer research.
EDARADD is a critical adaptor protein that acts as a key regulator in the NF-kappa-B signaling pathway, which plays a pivotal role in inflammatory and immune responses. Dysregulation of this pathway has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of EDARADD can provide valuable insights for the development of therapeutics targeting NF-kappa-B signaling and its associated pathways.
Product Name:
EDARADD Rabbit Polyclonal Antibody
SKU:
CAB15951
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2).
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
128178
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using EDARADD Rabbit pAb (CAB15951) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
