EDARADD Rabbit Polyclonal Antibody (CAB15950)
- SKU:
- CAB15950
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | EDARADD Rabbit Polyclonal Antibody |
SKU: | CAB15950 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human EDARADD (NP_665860.2). |
Sequence: | MGLR TTKQ MGRG TKAP GHQE DHMV KEPV EDTD PSTL SFNM SDKY PIQD TELP KAEE CDTI TLNC PRNS DMKN QGEE NGFP DSTG DPLP EISK DNSC KENC TCSS CLLR APTI SDLL NDQD LLDV IRIK LDPC HPTV KNWR NFAS KWGM SYDE LCFL EQRP QSPT LEFL LRNS QRTV GQLM ELCR LYHR ADVE KVLR RWVD EEWP KRER GDPS RHF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CR; ED3; EDA3; ECTD11A; ECTD11B; EDARADD |
Positive Sample: | A-431,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 25kDa |
Observed MW: | 25kDa |
This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method: | Affinity purification |
Gene ID: | 128178 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |