The ECSCR Polyclonal Antibody (PACO53986) is a valuable tool for researchers studying the Endothelial Cell Specific Molecule 1 (ECSCR), a protein involved in vascular and immune system functions. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for various experimental applications including Western blotting.ECSCR is known to play a key role in regulating endothelial cell function and angiogenesis, making it a potential target for therapeutic interventions in cardiovascular diseases and cancer.
By enabling the detection and analysis of ECSCR protein expression in different cell types, this antibody serves as an essential tool for investigating the molecular mechanisms underlying vascular biology and immune responses.With its ability to facilitate the study of ECSCR in various research settings, the ECSCR Polyclonal Antibody (PACO53986) holds promise for advancing our understanding of endothelial cell biology and the development of targeted therapies for conditions related to vascular dysfunction.
Immunohistochemistry of paraffin-embedded human lung tissue using PACO53986 at dilution of 1:100.
Immunofluorescence staining of MCF-7 cells with PACO53986 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunofluorescence staining of A549 cells with PACO53986 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
ECSM2: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis via modulation of the actin cytoskeleton. Belongs to the ECSCR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytosol; plasma membraneBiological Process: negative regulation of angiogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
