The ECEL1 Polyclonal Antibody (PAC045786) is a valuable tool for researchers studying ECEL1, a cell surface protein involved in neurodevelopment and synaptic plasticity. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications including Western blot and immunohistochemistry.ECEL1, also known as endothelin-converting enzyme-like 1, plays a crucial role in the development and function of the nervous system, with implications for conditions such as epilepsy, autism, and neurodegenerative diseases.
By targeting ECEL1 with this antibody, researchers can investigate its expression, localization, and function in different cell types and tissues, paving the way for advancements in neuroscience research and potential therapeutic interventions.
ECEL1: May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. Belongs to the peptidase M13 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; EC 3.4.24.-; Membrane protein, integralChromosomal Location of Human Ortholog: 2q37.1Cellular Component: integral to plasma membraneMolecular Function: metallopeptidase activityBiological Process: respiratory system processDisease: Arthrogryposis, Distal, Type 5d
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
