The EBP Polyclonal Antibody (CAB14845) is an essential tool for researchers studying the EBP protein, a key enzyme involved in the biosynthesis of cholesterol and steroid hormones. This antibody, produced using rabbit immunization, demonstrates high specificity and sensitivity for detecting EBP in human samples, making it a reliable tool for Western blot applications.EBP, also known as emopamil-binding protein, plays a crucial role in maintaining lipid homeostasis and regulating cholesterol metabolism. Dysregulation of EBP has been linked to various lipid-related disorders, making it a promising target for therapeutic intervention.
By targeting EBP, researchers can gain insights into the mechanisms underlying these diseases and potentially develop new treatment strategies.With its ability to accurately detect EBP in various cell types, the EBP Polyclonal Antibody is an invaluable resource for studies in lipid metabolism, cardiovascular diseases, and endocrine disorders. By utilizing this antibody, researchers can further our understanding of EBP's function and its implications for health and disease.
Product Name:
EBP Rabbit Polyclonal Antibody
SKU:
CAB14845
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human EBP (NP_006570.1).
The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Purification Method:
Affinity purification
Gene ID:
10682
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EBP Rabbit pAb (CAB14845) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
