The EBF3 Polyclonal Antibody (CAB15973) is a crucial tool for researchers studying the EBF3 protein, a transcription factor involved in the development and function of B cells in the immune system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the EBF3 protein, this antibody allows for the detection and analysis of EBF3 expression in various cell types, making it an indispensable resource for studies in immunology and cancer research.
EBF3, also known as early B-cell factor 3, plays a critical role in the regulation of B cell differentiation and function, making it a key player in immune responses. Its involvement in B cell development and function makes it a promising target for research into diseases such as leukemia, lymphoma, and other immune-related disorders. By studying the role of EBF3, researchers can gain important insights into the mechanisms underlying these diseases and potentially develop novel therapeutic strategies targeting EBF3 activity.
Product Name:
EBF3 Rabbit Polyclonal Antibody
SKU:
CAB15973
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human EBF3 (NP_001005463.1).
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma.
Purification Method:
Affinity purification
Gene ID:
253738
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Rat thymus, using EBF3 Rabbit pAb (CAB15973) at 1:1500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
