The EBF2 Polyclonal Antibody (PAC047194) is a valuable tool for studying EBF2, a transcription factor that plays a key role in the development and function of B cells. This antibody, produced in rabbits, shows high specificity and sensitivity in detecting EBF2 in human samples, making it ideal for use in Western blot and immunohistochemistry applications.EBF2 is essential for B cell lineage commitment and maintenance, as well as for controlling B cell differentiation and antibody production.
Dysregulation of EBF2 has been linked to B cell malignancies and autoimmune diseases, highlighting its importance as a therapeutic target. By using the EBF2 Polyclonal Antibody, researchers can gain insights into the molecular mechanisms governing B cell development and function, aiding in the development of targeted therapies for various immune-related disorders.
Antibody Name:
EBF2 Antibody (PACO47194)
Antibody SKU:
PACO47194
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Transcription factor COE2 protein (53-254AA)
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO47194 at dilution of 1:100.
Background:
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' ().
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
