EAPP Antibody (PACO26369)
- SKU:
- PACO26369
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
EAPP Antibody (PACO26369)
The EAPP Monoclonal Antibody (PAC026369) is a powerful tool for studying EAPP, a novel protein involved in the regulation of cellular processes and immune response. This antibody, produced using cutting-edge technology, is highly specific to human samples and has been validated for use in various applications, including immunofluorescence and flow cytometry.EAPP, also known as Enhancer of ALP/PLAP, has been implicated in promoting cell growth and differentiation, making it a potential target for cancer research and regenerative medicine.
By targeting EAPP and understanding its functions, researchers can gain valuable insights into cellular pathways and develop potential therapies for various diseases.This monoclonal antibody provides researchers with a reliable tool for detecting and studying EAPP in different cell types and experimental setups. Its high specificity and sensitivity make it an essential component in the investigation of EAPP-related mechanisms and pathways, paving the way for new discoveries in cell biology and therapeutic development.
| Antibody Name: | EAPP Antibody (PACO26369) |
| Antibody SKU: | PACO26369 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human E2F-associated phosphoprotein protein (1-285AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: 293 whole cell lysate All lanes: EAPP antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 33 kDa Observed band size: 33 kDa . |
 | IHC image of PACO26369 diluted at 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. |
| Synonyms: | E2F-associated phosphoprotein (EAPP), EAPP, C14orf11 |
| UniProt Protein Function: | EAPP: May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. Interacts with E2F1. The C-terminal half binds the N- terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4. Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.Chromosomal Location of Human Ortholog: 14q13.1Cellular Component: cytoplasm; Golgi apparatus; nucleusBiological Process: positive regulation of cell proliferation; positive regulation of RNA elongation from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q56P03 |
| NCBI GenInfo Identifier: | 296439474 |
| NCBI Gene ID: | 55837 |
| NCBI Accession: | Q56P03.4 |
| UniProt Secondary Accession: | Q56P03,Q9BVF4, Q9NWV5, Q9NZ86 |
| UniProt Related Accession: | Q56P03 |
| Molecular Weight: | 32,762 Da |
| NCBI Full Name: | E2F-associated phosphoprotein |
| NCBI Synonym Full Names: | E2F associated phosphoprotein |
| NCBI Official Symbol: | EAPPÂ Â |
| NCBI Official Synonym Symbols: | BM036; C14orf11Â Â |
| NCBI Protein Information: | E2F-associated phosphoprotein |
| UniProt Protein Name: | E2F-associated phosphoprotein |
| UniProt Synonym Protein Names: | |
| Protein Family: | E2F-associated phosphoprotein |
| UniProt Gene Name: | EAPPÂ Â |
| UniProt Entry Name: | EAPP_HUMAN |
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