The E7 Antibody (PAC034850) is a highly specific monoclonal antibody designed for research involving the E7 protein, a viral oncoprotein expressed by high-risk human papillomavirus (HPV) strains. This antibody is raised in mice and is validated for use in immunohistochemistry and Western blot applications.The E7 protein is known to play a significant role in HPV-associated cancers, particularly cervical cancer. By targeting the E7 protein, researchers can gain valuable insights into the mechanisms underlying HPV-driven tumorigenesis and potentially identify novel therapeutic targets for the treatment of HPV-related malignancies.
This antibody offers high specificity and sensitivity in detecting the E7 protein in various sample types, making it an invaluable tool for studies in virology, oncology, and immunology. Its ability to accurately detect and quantify E7 protein levels makes it ideal for investigating the role of HPV in cancer development and progression.Overall, the E7 Antibody (PAC034850) is a crucial tool for researchers looking to expand their understanding of HPV-associated cancers and develop novel strategies for combating these deadly diseases.
Antibody Name:
E7 Antibody (PACO34850)
Antibody SKU:
PACO34850
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human papillomavirus type 18
Immunogen:
Recombinant Human papillomavirus type 18 Protein E7 protein (1-105AA)
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.
Synonyms:
Protein E7, E7
UniProt Protein Function:
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.
