The E6 Antibody (PAC034958) is a valuable tool for researchers studying the E6 protein, a key player in the development of cancers caused by human papillomavirus (HPV) infection. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in a variety of applications, including Western blot and immunohistochemistry.The E6 protein is known for its ability to interact with multiple cellular proteins, leading to the degradation of tumor suppressor proteins and the dysregulation of essential cell processes. By targeting the E6 protein, researchers can gain insights into the molecular mechanisms driving HPV-induced carcinogenesis, paving the way for the development of novel therapeutic strategies and diagnostic tools.
Given the pivotal role of the E6 protein in HPV-related cancers, the E6 Antibody (PAC034958) is a valuable resource for investigators seeking to unravel the complexities of this disease pathway and identify potential targets for intervention. Its specificity and sensitivity make it an essential reagent for studies in oncology, virology, and molecular biology.
Antibody Name:
E6 Antibody (PACO34958)
Antibody SKU:
PACO34958
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human papillomavirus type 16
Immunogen:
Recombinant Human papillomavirus type 16 Protein E6 protein (1-158AA)
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon α resulting in inhibition of the interferon signaling pathway.
Synonyms:
Protein E6, E6
UniProt Protein Function:
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
