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E2F4/E2F5 Antibody (PACO00732)

SKU:
PACO00732
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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E2F4/E2F5 Antibody (PACO00732)

The E2F4/E2F5 Polyclonal Antibody (PACO00732) is a valuable tool for research involving the E2F4 and E2F5 transcription factors, which play key roles in cell cycle control and proliferation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the E2F4/E2F5 proteins, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.

E2F4 and E2F5 are essential regulators of cell cycle progression and are implicated in the development of numerous cancers. Understanding their function and activity is crucial for unraveling the mechanisms of tumorigenesis and identifying potential targets for cancer therapy. The E2F4/E2F5 Polyclonal Antibody provides researchers with a powerful tool to investigate the role of these transcription factors in health and disease, ultimately contributing to advancements in the field of oncology.

Antibody Name:E2F4/E2F5 Antibody
Antibody SKU:PACO00732
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat, Monkey
Immunogen:synthesized peptide derived from the Internal region of human E2F-4/5.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:E2F4; Transcription factor E2F4; E2F-4; E2F5; Transcription factor E2F5; E2F-5
UniProt Protein Function:E2F4: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Belongs to the E2F/DP family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 16q22.1Cellular Component: nucleoplasm; transcription factor complexMolecular Function: protein domain specific binding; protein binding; DNA binding; transcription factor activity; transcription factor bindingBiological Process: G1/S-specific transcription in mitotic cell cycle; transcription initiation from RNA polymerase II promoter; organ morphogenesis; transcription, DNA-dependent; blood circulation; transforming growth factor beta receptor signaling pathway; epithelial cell development; gene expression; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; cell volume homeostasis; regulation of cell size; regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
UniProt Code:Q16254
NCBI GenInfo Identifier:2494229
NCBI Gene ID:1874
NCBI Accession:Q16254.2
UniProt Secondary Accession:Q16254,Q12991, Q15328, A6NGR8, B5BU56
UniProt Related Accession:Q16254
Molecular Weight:43,960 Da
NCBI Full Name:Transcription factor E2F4
NCBI Synonym Full Names:E2F transcription factor 4, p107/p130-binding
NCBI Official Symbol:E2F4  
NCBI Official Synonym Symbols:E2F-4  
NCBI Protein Information:transcription factor E2F4; p107/p130-binding protein
UniProt Protein Name:Transcription factor E2F4
UniProt Synonym Protein Names:
Protein Family:Transcription factor
UniProt Gene Name:E2F4  
UniProt Entry Name:E2F4_HUMAN

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