E2F1 Rabbit Polyclonal Antibody (CAB2067)
- SKU:
- CAB2067
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | E2F1 Rabbit Polyclonal Antibody |
SKU: | CAB2067 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-301 of human E2F1 (NP_005216.1). |
Sequence: | GGRL EGLT QDLR QLQE SEQQ LDHL MNIC TTQL RLLS EDTD SQRL AYVT CQDL RSIA DPAE QMVM VIKA PPET QLQA VDSS ENFQ ISLK SKQG PIDV FLCP EE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:20 - 1:100 |
Synonyms: | RBP3; E2F-1; RBAP1; RBBP3; E2F1 |
Positive Sample: | HeLa,A-431,HT-29 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 47kDa |
Observed MW: | 60kDa |
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Purification Method: | Affinity purification |
Gene ID: | 1869 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |