E2F1 Rabbit Polyclonal Antibody (CAB16720)
- SKU:
- CAB16720
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | E2F1 Rabbit Polyclonal Antibody |
SKU: | CAB16720 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-437 of human E2F1 (NP_005216.1). |
Sequence: | ETVG GISP GKTP SQEV TSEE ENRA TDSA TIVS PPPS SPPS SLTT DPSQ SLLS LEQE PLLS RMGS LRAP VDED RLSP LVAA DSLL EHVR EDFS GLLP EEFI SLSP PHEA LDYH FGLE EGEG IRDL FDCD FGDL TPLD F |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | RBP3; E2F-1; RBAP1; RBBP3; E2F1 |
Positive Sample: | mouse brain,rat brain,rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 47kDa |
Observed MW: | 70kDa |
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Purification Method: | Affinity purification |
Gene ID: | 1869 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |