The Dystrophin Polyclonal Antibody (CAB1411) is a valuable tool for researchers studying dystrophin, a protein crucial for muscle health and function. Dystrophin plays a key role in maintaining the structural integrity of muscle cells, and mutations in the dystrophin gene are associated with muscular dystrophies.This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to dystrophin, researchers can detect and analyze this important protein in a variety of cell types, making it an excellent choice for studies in muscle biology and neuromuscular diseases.
Understanding the function and regulation of dystrophin is essential for developing therapies for muscular dystrophies and related conditions. The Dystrophin Polyclonal Antibody offers a reliable and sensitive tool for investigating the role of dystrophin in health and disease, helping to advance our knowledge and potentially lead to new treatment options for patients.
Product Name:
Dystrophin Rabbit Polyclonal Antibody
SKU:
CAB1411
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 346-635 of human Dystrophin (NP_003997.2).
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene.
Purification Method:
Affinity purification
Gene ID:
1756
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Dystrophin Rabbit pAb (CAB1411) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
