The Dystrobrevin Alpha Polyclonal Antibody (CAB12067) is a key tool for researchers studying the Dystrobrevin Alpha protein, which is involved in maintaining the stability and function of muscle cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications. By targeting the Dystrobrevin Alpha protein, researchers can gain valuable insights into its role in muscle cell function and potential implications in muscle-related disorders.Dystrobrevin Alpha is a crucial component of the dystrophin-associated protein complex, which helps anchor muscle fibers to the extracellular matrix and provides structural support during muscle contraction. Dysregulation of Dystrobrevin Alpha has been linked to various muscular dystrophies and muscle-wasting conditions, highlighting its importance in muscle health.
Studying the expression and localization of Dystrobrevin Alpha using this antibody can provide valuable information for understanding muscle physiology and identifying potential therapeutic targets for muscle disorders.Researchers in the fields of muscle biology, physiology, and muscle-related diseases can benefit from the use of the Dystrobrevin Alpha Polyclonal Antibody (CAB12067) to further investigate the function and regulation of this critical protein. Its high specificity and reliability make it a valuable tool for advancing research in muscle biology and developing targeted approaches for treating muscle disorders.
Product Name:
DTNA Rabbit Polyclonal Antibody
SKU:
CAB12067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 240-480 of human DTNA (NP_001381.2).
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1837
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DTNA Rabbit pAb (CAB12067) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
