The Dystonin Polyclonal Antibody (CAB2013) is a valuable tool for researchers studying dystonin, a protein involved in cell structure and function. This antibody, raised in rabbits, is highly specific for detecting dystonin in human samples and is validated for use in Western blot applications. By targeting the dystonin protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and neurology.Dystonin, also known as bullous pemphigoid antigen 1, is a cytoskeletal protein that plays a crucial role in maintaining cell structure and integrity.
Mutations in the dystonin gene have been linked to various diseases, including muscular dystrophy and neuropathy. Understanding the function of dystonin is important for uncovering its role in disease pathology and developing potential therapeutic interventions.This polyclonal antibody provides researchers with a reliable tool for investigating the function of dystonin in various physiological and pathological contexts. Its specificity and sensitivity make it a valuable resource for advancing our understanding of dystonin biology and its implications for human health.
Product Name:
DST Rabbit Polyclonal Antibody
SKU:
CAB2013
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DST (NP_001714.1).
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.
Purification Method:
Affinity purification
Gene ID:
667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using DST Rabbit pAb (CAB2013) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
