The DYRK3 Antibody (PAC026365) is a high-quality polyclonal antibody designed for researchers studying the DYRK3 protein, a key regulator of cell growth and division. This antibody, generated in rabbits, displays strong reactivity with human samples and has been validated for use in Western blot applications.DYRK3 is a dual-specificity kinase that plays a crucial role in cell cycle progression, apoptosis, and DNA damage response. Dysregulation of DYRK3 has been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, studying DYRK3 activity and expression levels is essential for understanding its function in health and disease.
This antibody specifically binds to DYRK3, allowing for accurate detection and analysis in different cell types. Its versatility makes it suitable for a wide range of research applications, particularly in the fields of cell biology, oncology, and neurology. By investigating the role of DYRK3, researchers can uncover new insights into cellular pathways and potentially identify novel therapeutic targets for various diseases.
Antibody Name:
DYRK3 Antibody (PACO26365)
Antibody SKU:
PACO26365
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 3 protein (1-300AA)
IHC image of PACO26365 diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
DYRK3: a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Expressed primarily in erythroid progenitor cells and regulates late erythropoiesis. Protein type: Protein kinase, dual-specificity (non-receptor); EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; CMGC group; DYRK family; Dyrk2 subfamilyChromosomal Location of Human Ortholog: 1q32.1Cellular Component: nucleusMolecular Function: ATP binding; magnesium ion binding; protein kinase activityBiological Process: erythrocyte differentiation; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
